Open Access Case report

Oncocytic-type intraductal papillary mucinous neoplasm (IPMN)-derived invasive oncocytic pancreatic carcinoma with brain metastasis - a case report

Kun-Chun Chiang1,2†, Chi-Chang Yu3†, Jim-Ray Chen4, Yu-Ting Huang5, Cheng-Cheng Huang4, Chun-Nan Yeh3, Chien-Sheng Tsai6, Li-Wei Chen7, Hsien-Cin Chen8, Jun-Te Hsu3, Cheng-Hsu Wang10,9* and Huang-Yang Chen1,10*

Author Affiliations

1 General Surgery Department, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

2 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 333, Taiwan

3 General Surgery Department, Chang Gung Memorial Hospital, 5, Fu-Hsing Street, Kwei-Shan, Taoyuan, 333, Taiwan

4 Department of Pathology, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

5 Department of Radiology, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

6 Department of Radiation Oncology, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

7 Department of Gastroenterolgy, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

8 Department of Neurosurgery, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

9 Department of Hematology and Oncology, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan

10 200, Lane 208, Jijin 1st Road, Keelung, 20445, Taiwan

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World Journal of Surgical Oncology 2012, 10:138 doi:10.1186/1477-7819-10-138

Published: 9 July 2012

Abstract

Pancreatic cancer is a lethal disease without effective treatments at present. It ranks as s as 4th and 5th in cancer-related mortality in the western countries and worldwide. Locally advanced pancreatic duct carcinoma (PDAC) and metastatic PDAC, usually found the metastases over liver, peritoneum, or lung, have been shown to be with dismal prognosis. Brain metastasis is a rare entity and most cases reported before were found post-mortem. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) has been deemed as a precursor of PDAC with very slow progression rate. Here we reported a case diagnosed with IPMN-derived PDAC with brain metastasis. After surgeries for PDAC and brain metastasis, subsequent chemotherapy and radiotherapy were also given. One and half year after surgery, this patient is still living with good performance status, which may warrant individualization of therapeutic strategy for PDAC with only brain metastasis.

Keywords:
Brain metastasis; IPMN; Pancreatic cancer; Oncocytic IPMN