Autologous formalin-fixed tumor vaccine suppressed re-recurrence of HCV-related hepatocellular carcinoma following 29 unsuccessful treatments with extensive conventional therapy: a case report
1 Inui Cancer Immunotherapy Clinic, 6-14-17 Kinndachou, Moriguchi-shi, Osaka, 570-0011, Japan
2 Cell-Medicine, Inc., Sengen 2-1-6, Tsukuba Science City, Ibaraki, 305-0047, Japan
3 Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan
World Journal of Surgical Oncology 2012, 10:144 doi:10.1186/1477-7819-10-144Published: 12 July 2012
Treatment of hepatocellular carcinoma (HCC) with autologous formalin-fixed tumor vaccine after primary resection has been shown to suppress the recurrence of hepatitis B virus-associated HCC, but the effect of this treatment on hepatitis C virus (HCV)-related disease has not yet been clarified. Here, we report a case of a patient with repeat recurrent HCC that was associated with HCV who had endured 29 episodes of HCC recurrence despite a variety of therapy using conventional methods. Finally, treatment with a single course of autologous formalin-fixed tumor vaccine resulted in suppression of potential further re-recurrence of HCC for more than 43 months without any additional treatment.