Castleman disease mimicked pancreatic carcinoma: report of two cases
1 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affliliated Hospital,School of Medicine, Zhejiang University, 79 Qingchun Street, Zhejiang Province, Hangzhou, 310003, China
2 Key laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, 79 Qingchun Street, Zhejiang Province, Hangzhou, 310003, China
3 Key laboratory of Organ Transplantation of Zhejiang Province, 79 Qingchun Street, Zhejiang Province, Hangzhou, 310003, China
World Journal of Surgical Oncology 2012, 10:154 doi:10.1186/1477-7819-10-154Published: 23 July 2012
Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old woman were detected to have a pancreatic mass in the routine medical examinations. Both of them were asymptomatic. The computed tomography and ultrasonographic examination revealed a mild enhancing solitary mass at the pancreatic head/neck. No definite preoperative diagnosis was established and Whipple operations were originally planned. The intraoperative frozen section diagnosis of both patients revealed lymphoproliferation. Then the local excisions of mass were performed. Histological examination revealed features of CD of hyaline-vascular type. No recurrence was found during the follow-up period. CD should be included in the differential diagnosis of pancreatic tumors. Local excision is a suitable surgical choice.