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Open Access Case report

Association of carcinoid tumor and low grade glioma

Emeline Tabouret12*, Maryline Barrié2, Cecile Vicier1, Anthony Gonçalves1, Olivier Chinot2, Patrice Viens1 and Anne Madroszyk1

Author Affiliations

1 Département d’Oncologie Médicale, Institut Paoli-Calmettes, 232 Boulevard Ste Marguerite, 13009, Marseille, France

2 Service de Neuro-Oncologie, Assistance Publique des Hôpitaux de Marseille, Hôpital de le Timone, Marseille, France

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World Journal of Surgical Oncology 2012, 10:236  doi:10.1186/1477-7819-10-236

Published: 8 November 2012

Abstract

Background

Lung carcinoid tumor and low grade glioma are two uncommon malignancies.

Patients and methods

We report the case of 24-year-old man who presented with respiratory disease. Imaging investigations showed a right lung tumor and histological analysis confirmed a typical carcinoid tumor. As part of initial staging, brain MRI revealed an asymptomatic right frontal lesion. First, a right pulmonary lobectomy was performed without adjuvant treatment. In second time, brain tumorectomy was performed. Histological examination confirmed the diagnosis of low grade glioma (LGG). The patient remained in complete remission 2.5 years after the initial diagnosis.

Results

This is the first case reporting the association between LGG and lung carcinoid tumor, while no association between LGG and a systemic tumor have been published to date. Association of lung carcinoid tumor with other malignant diseases has been reported but remained uncommon. Only minimal data support a potential molecular common origin.

Conclusion

This exceptional association may be fortuitous. However, their concomitant diagnoses suggest a potential association between both rare diseases. A genetic susceptibility remains possible.