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Myxofibrosarcoma of the sinus piriformis: case report and literature review

Zhu Qiubei1, Lin Cheng2, Xu Yaping1, Lin Shunzhang1 and Fan Jingping1*

Author Affiliations

1 Department of ear, nose and throat, Changzheng Hospital, No 415, Fengyang Road, Shanghai, Huangpu District, 200003, China

2 Department of ear, nose and throat, The 452nd Hospital of PLA, Gongnongyuan Street, Chengdu, Sichuan Province, China

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World Journal of Surgical Oncology 2012, 10:245  doi:10.1186/1477-7819-10-245

Published: 15 November 2012


Myxofibrosarcoma is a common sarcoma in the extremities of older people, but is rare in the head and neck region. Here, we report the case of a 42-year-old male patient in whom myxofibrosarcoma generated from the sinus piriformis. Histopathologically, the tumor was characterized by spindle cellular proliferation with moderate cellular density in fibromyxoid stroma. Immunohistochemically, the tumor cells showed positive reactivity for vimentin, Ki-67, smooth muscle actin, and CD34, but negative staining for S-100. Based on these results, the tumor was diagnosed as a low-grade myxofibrosarcoma. Resection of the tumor was performed via a transcervical approach. The patient’s postoperative clinical course was uneventful and no local recurrence or distant metastasis has been found so far. The pathology, clinical characteristics, and treatment of myxofibrosarcoma are also reviewed.

Myxofibrosarcoma; Sinus piriformis