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Two-stage hepatectomy after autologous CD133+ stem cells administration: a case report

Eloisa Franchi, Maria C Canepa, Andrea Peloso, Letizia Barbieri, Laura Briani, Gabor Panyor, Paolo Dionigi and Marcello Maestri*

Author Affiliations

Fondazione IRCCS Policlinico San Matteo, and University of Pavia, Viale Camillo Golgi 19, Pavia 27100PV, Italy

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World Journal of Surgical Oncology 2013, 11:192  doi:10.1186/1477-7819-11-192

Published: 13 August 2013

Abstract

Liver resection is the mainstay of treatment for patients with primary and metastatic liver tumors. However, a large majority of patients present for initial medical evaluation with primary and metastatic liver tumors when their cancer is unresectable. Several trials have been undertaken to identify alternative treatments and complementary therapies. In the near future, the field of liver surgery will aim to increase the number of patients that can benefit from resection, since radical removal of the tumor currently provides the sole chance of cure. This paper reports the case of a patient with an advanced colonic cancer in the era of stem cell therapyIn 2011, a 57 years old white Caucasian man with a previous history of non-Hodgkin lymphoma (NHL) was diagnosed with colon cancer and bilobar liver metastases. Following neoadjuvant therapy, the patient was enrolled in a protocol of stem cell administration for liver regeneration. Surgery was initially performed on the primary cancer and left liver lobe. An extended right lobectomy to S1 was then performed after a portal vein embolization (PVE) and stem cell stimulation of the remaining liver. The postoperative course was uneventful and the patient was free of disease after 12 months. Extreme liver resection can provide a safer option and a chance of cure to otherwise unresectable patients when liver regeneration is boosted by PVE and stem cell administration.

Keywords:
Liver surgery; Portal vein embolization; Stem cells; Liver regeneration; Colon cancer; Liver metastases