Open Access Open Badges Case report

Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast

Giancarlo Balbi14*, Luca Di Martino1, GianPaolo Pitruzzella2, Diego Pitruzzella2, Flavio Grauso1, Antonella Napolitano1, Elisabetta Seguino1, Francesco Gioia1 and Pasquale Orabona3

Author Affiliations

1 U.O. Ginecologia ed Ostetricia, Seconda Università degli Studi di Napoli, c/o S. Anna e S. Sebastiano Hospital, Caserta, Italy

2 U.O.S.D. Breast Unit, S. Anna e S. Sebastiano Hospital, Caserta, Italy

3 U.O.C. Anatomic Pathology, S. Anna e S. Sebastiano Hospital, Caserta, Italy

4 Department Obstetrics and Gynaecology and Reproduction, University of study of Naples, Largo Madonna Delle Grazie, 1, Napoli 80138, Italy

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World Journal of Surgical Oncology 2013, 11:21  doi:10.1186/1477-7819-11-21

Published: 26 January 2013


The authors describe a case of undifferentiated pleomorphic sarcoma of the breast occurring in a 50-year-old woman who presented with a palpable mass in her right breast. She first noticed the mass one month previously. Core needle biopsy showed connective tissue including epithelioid and spindle cells. The patient underwent total mastectomy without axillary lymph node dissection. Based on examination of the excised tumor, the initial pathologic diagnosis was atypical spindle-shaped and ovoid cells with uncertain malignant potential. Histological findings with immunomarkers led to the final diagnosis of undifferentiated pleomorphic sarcoma.

This case highlights a rare and interesting variant of primary breast sarcoma and the important role of immunohistochemistry in defining histological type and differential diagnosis. Hence, undifferentiated pleomorphic sarcoma has been a diagnosis of exclusion performed through sampling and critical use of ancillary diagnostic techniques.

Breast neoplasm; Female; Immunohistochemistry; Sarcoma