Email updates

Keep up to date with the latest news and content from WJSO and BioMed Central.

Open Access Open Badges Case report

Soft tissue perineurioma of the tongue: report of a case and review of the literature

Wen-lin Xiao1*, Ling-fa Xue2 and Yao-xiang Xu1

Author Affiliations

1 Department of Oral and Maxillofacial Surgery, The Medical School Hospital of Qingdao University, No. 1677, Wutaishan Road, Qingdao 266555, People’s Republic of China

2 Department of Pathology, The Medical School Hospital of Qingdao University, No. 1677, Wutaishan Road, Qingdao, People’s Republic of China

For all author emails, please log on.

World Journal of Surgical Oncology 2014, 12:11  doi:10.1186/1477-7819-12-11

Published: 13 January 2014


Perineurioma is a rare benign tumor of the peripheral nervous system distinct from schwannomas and neurofibromas. It may be intraneural or extraneural (in the soft tissue). Extraneural soft tissue perineuriomas are uncommon; rare cases have been reported in the oral cavity. We present a case of soft tissue perineurioma in the tip of the tongue. The tumor was characterized by slender spindle cells, arranged in short fascicles or whorls, and focal areas showing a distinct storiform pattern. Tumor cells showed the immunohistochemical profile of perineurial cells, including epithelial membrane antigen. Smooth muscle actin, S-100, and CD34 were not expressed by the tumor cells. The tumor was surgically excised and in 2 years there has been no recurrence. Knowledge of the tumor in the oral cavity is important to reach a correct diagnosis and to avoid unnecessary aggressive local excision.

Perineurioma; Soft tissue; Tongue