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Intrahepatic cholangiocarcinoma in a transplant liver - selective internal radiation therapy followed by right hemihepatectomy: report of a case

Jens Sperling13, Christoph Justinger23, Jochen Schuld3, Christian Ziemann3, Roland Seidel4 and Otto Kollmar13*

Author Affiliations

1 Present address: Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg August University, D-37075 Göttingen, Germany

2 Present address: Department of General and Visceral Surgery, Städtisches Klinikum Karlsruhe, D-76133 Karlsruhe, Germany

3 Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, D-66421 Homburg-Saar, Germany

4 Department of Diagnostic and Interventional Radiology, University of Saarland, D-66421 Homburg-Saar, Germany

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World Journal of Surgical Oncology 2014, 12:198  doi:10.1186/1477-7819-12-198

Published: 1 July 2014


Intra- or extrahepatic cholangiocarcinomas are the second most common primary liver malignancies behind hepatocellular carcinoma. Whereas the incidence for intrahepatic cholangiocarcinoma is rising, the occurrence of extrahepatic cholangiocarcinoma is trending downwards. The treatment of choice for intrahepatic cholangiocarcinoma remains liver resection. However, a case of liver resection after selective internal radiation therapy in order to treat a recurrent intrahepatic cholangiocarcinoma in a transplant liver is unknown in the literature so far. Herein, we present a case of a patient undergoing liver transplantation for Wilson’s disease with an accidental finding of an intrahepatic cholangiocarcinoma within the explanted liver. Due to a recurrent intrahepatic cholangiocarcinoma after liver transplantation, a selective internal radiation therapy with yttrium-90 microspheres was performed followed by right hemihepatectomy. Four years later, the patient is tumor-free and in a healthy condition.

Liver transplantation; Liver resection; Intrahepatic cholangiocarcinoma; Selective internal radiation therapy