Case report

A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass

Giorgio Carlomagno¹ and Pasquale Beneduce²

¹  Università di Roma "La Sapienza" – Corso di Laurea in Ostetricia, U. O. C. Ginecologia e Ostetricia – A.O. "G. Rummo", Benevento, Italy

²  U. O. C. Chirurgia d'Urgenza – A. O. 'U Rummo", Benevento, Italy

author email corresponding author email

World Journal of Surgical Oncology 2004, 2:15doi:10.1186/1477-7819-2-15

Published:	13 May 2004

Abstract

Background

Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Myogenic gastrointestinal stromal tumor, a distinctive morphologic variant is characterized by an unusually prominent myxoid stromal background.

Case presentation

We report a case of myxoid variant of GIST in a 42 years old woman presenting as an epigastric mass associated to an ovarian cyst and elevated CA-125. Histologically, the lesions was composed of a proliferation of spindle cells in an abundant myxoid stroma, without evidence of atypia or anaplasia. Immunohistochemical stains showed strong positive staining with muscle actin, positive staining with CD34 and weak positive staining with CD117, while showed negative for S-100.

Conclusion

At surgery every effort should be made to identify the origin of the tumor. A complete surgical removal of the tumor should be obtained, as this is the only established treatment that offers long term survival.