Figure 2.

Photomicrographs (×200) showing H&E staining of tumours of (a) BP-4 (b) control M (c) control P groups. Increased areas of necrosis (arrow) and decreased cellular density are present in BP-4 treated tumours when compared to control groups. (d) Showing cell death score of tumours. The animals received a single administration of either saline or gene construct with and without BP-4 along with colorectal cancer cells. Results are shown as mean ± SEM of 6 animals in each group. (e) Showing average numbers of mitotic figures per section per field of tumours. Values are expressed as mean ± SEM of 6 animals in each group. (key: P – animals without plasmid therapy, M – animals which received control plasmid, BP-4 – animals which received IGFBP-4 gene.)