Case report

Hepatobiliary cystadenoma exhibiting morphologic changes from simple hepatic cyst shown by 11-year follow up imagings

Naoto Fukunaga¹ , Masashi Ishikawa¹ , Hisashi Ishikura¹ , Toshihiro Ichimori¹ , Suguru Kimura¹ , Akihiro Sakata¹ , Koichi Sato² , Jyunichi Nagata² and Yoshiyuki Fujii³

¹  Department of Surgery, Tokushima Red Cross Hospital, Komatsushima-City, Tokushima Prefecture, Japan

²  Department of Gastroenteology, Tokushima Red Cross Hospital, Komatsushima-City, Tokushima Prefecture, Japan

³  Department of Pathology, Tokushima Red Cross Hospital, Komatsushima-City, Tokushima Prefecture, Japan

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World Journal of Surgical Oncology 2008, 6:129doi:10.1186/1477-7819-6-129

Published:	11 December 2008

Abstract

Background

A long-term follow up case of hepatobiliary cystadenoma originating from simple hepatic cyst is rare.

Case presentation

We report a case of progressive morphologic changes from simple hepatic cyst to hepatobiliary cystadenoma by 11 – year follow up imaging. A 25-year-old man visited our hospital in 1993 for a simple hepatic cyst. The cyst was located in the left lobe of the liver, was 6 cm in diameter, and did not exhibit calcification, septa or papillary projections. No surgical treatment was performed, although the cyst was observed to gradually enlarge upon subsequent examination. The patient was admitted to our hospital in 2004 due to epigastralgia. Re-examination of the simple hepatic cyst revealed mounting calcification and septa. Abdominal CT on admission revealed a hepatic cyst over 10 cm in diameter and a high-density area within the thickened wall. MRI revealed a mass of low intensity and partly high intensity on a T1-weighted image. Abdominal angiography revealed hypovascular tumor. The serum levels of AST and ALT were elevated slightly, but tumor markers were within normal ranges. Left lobectomy of the liver was performed with diagnosis of hepatobiliary cystadenoma or hepatobiliary cystadenocarcinoma. The resected specimen had a solid component with papillary projections and the cyst was filled with liquid-like muddy bile. Histologically, the inner layer of the cyst was lined with columnar epithelium showing mild grade dysplasia. On the basis of these findings, hepatobiliary cystadenoma was diagnosed.

Conclusion

We believe this case provides evidence of a simple hepatic cyst gradually changing into hepatobiliary cystadenoma.