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Small cell carcinoma in ulcerative colitis - new treatment option: a case report

Christoforos Kosmidis*, Christoforos Efthimiadis, Georgios Anthimidis, Kalliopi Vasiliadou, Ioanna Tzeveleki, Panagiotis Fotiadis and Georgios Basdanis

Author Affiliations

Department of Surgery, Interbalkan European Medical Center, Thessaloniki, Greece

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World Journal of Surgical Oncology 2010, 8:100  doi:10.1186/1477-7819-8-100

Published: 18 November 2010



The most common type of carcinoma associated with ulcerative colitis (UC) is adenocarcinoma. We present a case of primary rectal small cell carcinoma in a patient with a history of UC.


A 34-year-old male diagnosed with UC for 10 years was not consistent with the usual annual follow-up and presented with mucoid-bloody diarrhea. Colonoscopy revealed a rectal mass 2 cm distant from the anal verge. The patient underwent a total proctocolectomy with preservation of the anal sphincters, construction of an ileal reservoir, anastomosis of the reservoir to the anus (J configuration) and protective loop ileostomy.


Histological examination showed undifferentiated small cell carcinoma.


This is the first case of small cell carcinoma in a background of UC reported to be treated surgically and the patient and has no reccurence 18 months postoperatively.