Skip to main content

Leiomyosarcoma of intravascular origin - a rare tumor entity: clinical pathological study of twelve cases

Abstract

Background

Leiomysarcoma of intravascular origin is an exceedingly rare entity of malignant soft tissue tumors. They are most frequently encountered in the retroperitoneum arising from the inferior vena cava and are scarcely found to arise from vessels of the extremities. These tumors were analysed with particular reference to treatment outcome and prognosis. The aim of this article is to broaden the knowledge of the clinical course of this rare malignancy.

Method

During 2000 and 2009 twelve patients were identified with an intravascular origin of a leiomyosarcoma. Details regarding the clinical course, follow-up and outcome were assessed with focus on patient survival, tumor relapse and metastases and treatment outcome. 3 year survival probability was calculated using Kaplan-Meier method.

Results

Vascular leiomyosarcomas accounted for 0.7% of all malignant soft tissue tumors treated at our soft tissue sarcoma reference center. The mean follow up period was 38 months. Tumor relapse was encountered in six patients. 6 patients developed metastatic disease. The three year survival was 57%.

Conclusion

Vascular leiomysarcoma is a rare but aggressive tumor entity with a high rate of local recurrence and metastasis.

Background

Malignant soft tissue tumors account for < 1% of malignant tumors in adults [1], Leiomyosarcomas make up only < 5% of these rare soft tissue tumors [2].

Intraabdominal, retroperitoneal, cutaneous, subcutaneous and vascular growth patterns can be distinguished. Vascular leiomyosarcoma arises from major blood vessels and originates directly from the muscular wall of these vessels.

Up to 75% [3] arise from the retroperitoneal course of the inferior vena cava [4]. As with other soft tissue sarcomas clinical presentation may be delayed due to their deep origin. Presentation include palpable masses or intraluminal obstruction with signs of venous stases, thrombosis or embolism. Extracaval venous branches are a particularly rare source of vascular leiomyosarcomas and most frequently involve venous branches of the lower extremity [4]. Due to its rare incidence and the unusual clinical course the diagnosis and special treatment requirements are often challenging for the multidisciplinary team. We reviewed our experience with vascular leiomysarcomas with special reference to the clinical course and outcome. Differential diagnosis, clinical and pathological criteria will be discussed.

Methods and Materials

A search of our prospectively updated soft tissue tumor database revealed 182 patients diagnosed with a leiomyosarcoma from 2000 to 2009 at the BG University Hospital Bergmannsheil. Twelve of these tumors had an intravascular origin. Patients' notes were evaluated and patients and their physicians were contacted for details regarding the clinical course, follow-up and outcome. Follow-up imagine was obtained for all patients and included chest X-ray or CT scan, abdominal ultrasound, CT or MRI scan of the tumor site.

Local recurrence was defined as tumor relapse at the primary tumor resection site and metastatic disease was defined as tumor growth at any other site. Results are presented as means and standard deviation. Three year survival was calculated using the Kaplan - Meier method.

Due to the small number of patients we refrained from further statistical analysis.

Histology

Histological slides of the primary tumor were (re-) assessed by a pathologist* with expertise in soft tissue pathology from the Institute of Pathology, BG University Hospital Bergmannsheil. In all cases additional immunohistochemistry was performed to confirm the diagnosis. Second expert opinions from another pathologists were obtained in two cases. The primary diagnosis of an intravascular leiomyosarcoma of our institute was confirmed in both cases.

*The histopathological assessment by Prof. C.Kuhnen was carried out predominantly during his time at the Institute of Pathology, BG-University-Hospital "Bergmannsheil", Ruhr-University, Bochum, Germany

Results

1613 patients with a malignant soft tissue tumor (MSTT) were treated at our institute between 2000 and 2009. 182 tumors (11% of all MSTT) were diagnosed as leiomyosarcoma. Twelve of these tumors were of intravascular origin. Intravascular leiomyosarcoma accounted for 0.7% of all MSTT or 6% of all leiomyosarcomata. The mean age at the time of diagnosis was 59 years (± 10.7). Nine patients were females and three were males. The mean follow-up time from the time of definite surgery of the primary tumor was 38 months (± 30.6). The three year survival was 57%. Due to the insidious onset of the disease and late clinical symptoms the time between onset of tumor growth and the definite diagnosis could not be assessed.

The site of tumor growth was the lower extremity in 67%, the upper extremity in 25% and the vena cava in 8%.

In 50% the disease initially presented with signs of venous stasis. Deep venous thrombosis (n = 1), thrombophlebitis of the long saphenous vein (n = 2) and acute pulmonary embolism (n = 1) occurred as initial symptoms of the malignancy.

67% of the tumors were subfascial and 25% epifascial. In 33% the tumor originated from the femoral vein. Mean tumor size was 7.4 cm in largest diameter (± 3.0).

17% of the tumors were TI and 83% were TII.

At primary diagnosis no metastatic disease was detected in any patient.

According to the Coindre classification of tumor grading for soft tissue tumors, the tumors were subdivided in high grade (42%), intermediate (42%) and low grade (16%). (Table 1)

Table 1 Data of the patient collective and clinical course of the tumor disease.

Primary diagnosis was provided by incisional biopsy in two cases and punch biopsy in a further two cases prior to surgical ablation. Five patients were resected with microscopically positive margins at other institutes and were referred to our center for definitive ablation. One patient presented with the clinical symptoms of a wrist ganglion. After the initial tumor resection the histological assessment revealed a vascular leiomyosarcoma. The definite surgical intervention required a resection of the ulnar artery and accompanying vena comitantes. Two patients were transferred to our center after tumor relapse. One of them initially underwent vascular bypass surgery for a suspected malignant fibrous histiocytoma (NO. 2). The initial incorrect pathological assessment was benign. Tumor relapse led to the diagnosis of aleiomysarcoma. At that time the tumor surrounded the vascular prosthesis and hip implant. Amputation was discussed but refused by the patient. Palliative radiation therapy was initiated and the patient died five months later. In the other patient (NO. 12) during stripping of the long saphenous vein a tumor mass was encountered and the surgical specimen was sent for histology which demonstrated a leiomyosarcoma. The tumor was resected with positive margins. Despite adjuvant radiation therapy the tumor relapsed. The patient was then admitted to an oncology department where he received adjuvant chemotherapy before being transferred to our center for intervention. Surgery with curative intent required an extended hip amputation. At present there is no evidence of metastatic disease after 14 months.

Three patients had femoral vessel resection and a subsequent arterial bypass.

Patient NO. 7 required partial resection of the vessel wall of the inferior vena cava. In NO. 11&12 the tumor bearing segment of the long saphenous vein was resected. The ulnar artery and vein were resected in one patient.

Six patients received adjuvant radiation therapy of the primary tumor bed with a dose of 60 - 72 Gy. Three (NO. 2,4&9) of these patients died of the disease, one of them (NO. 2) received radiation therapy with palliative intention and one (NO. 4) had microscopically positive resection margins after surgical ablation.

Six patients (NO.1;2;,4;9;11 & 12) developed pulmonary metastasis, one patient also suffered from bone metastasis (NO.9), another one (NO.11) had additional liver metastasis. Five of these patients (NO.1;2;9;11 & 12) also developed recurrent disease. In further two patients (NO.1;2) pulmonary metastasis was suspected approximately 6 (NO.1) and 4 (NO.2) months after the definite operation but according to the patients' wishes no tests were done to confirm the metastatic disease. All but two (NO.11 & 12) patients with metastatic disease died (NO.1 eighteen months NO.2 six months NO4 ten months and NO9 twenty eight months after the final diagnosis was made). One patient received neoadjuvant chemotherapy (NO.9).

Five of these patients sought palliative chemotherapy (NO. 1, 4,10,11 & 12). Table 2

Table 2 Follow up data of the treatment related course

Macroscopic appearance

In all cases tumor growth in close proximity to vascular structures was present. On resection of the tumor bearing vessels the tumors were found to originate from structures of the vessels walls and to exhibit an intravascular tumor sprout. Figure 1

Figure 1
figure 1

Macroscopic appearance of a leiomysarcoma specimen after tumor resection at the wrist.

Microscopic appearance of the tumor

Histologically a spindle cell, mesenchymal neoplasm was found in all cases associated with the media of the vessel wall, which was assessed as site of tumor origin. The tumor cells were characteristically forming various fascicles and showed an eosinophilic cytoplasm with cigar shaped nuclei. Figure 2

Figure 2
figure 2

Histological appearance of a leiomyosarcoma after resection of a tumor in the subclavicular region. Notice the "cigar shaped" configuration of tumor cell nuclei with nuclear atypia (H&E staining).

The neoplasm derived from the media of the vessel wall and disrupted the existing vascular architecture. Immunohistochemically the majority of tumor cells displayed a positive reaction for smooth muscle actin and desmin, confirming smooth muscle differentiation of the tumor. Figure 3

Figure 3
figure 3

Intraluminal tumour growth of a Leiomyosarcoma originating from great saphenous vein (GSV) (H&E-staining). The subcutaneous adipose tissue is labelled SAT.

Discussion

Vascular leiomyosarcomata represent only a small proportion of soft tissue leiomyosarcomata [4]. All publications in the literature are of small clinical series or case reports. 11% of the patients treated for a malignant soft tissue tumor at the BG University Hospital Bergmannsheil presented with the leiomyosarcoma. The vascular leiomyosarcomas accounted for 6% of these tumors [5, 6] Svarvar et al. recognised an even sex distribution in his study of 225 patients with all types of leiomyosarcoma [6].

In the current series nine patients with a vascular leiomysarcoma were female and three male. In the series of patients with vascular leiomysarcoma from Berlin et al. 5 were males and 1 female [7], in Abed et al.´s group 9 were female and 7 male [5] and in Dzsinich et al.'s series 12 were female and 1 male [8].

These tumors mainly originate from the media of venous vessel walls, with rare exceptions in which they derive from the arterial vessel structures [9]. The tumor is encountered in the retroperitoneal course of the inferior vena cava in 75% of all intravascular leiomyosarcomata [3]. The patients in our study are mainly extremity soft tissue tumors.

Venous obstruction and a palpable tumor mass were the most common symptoms. Deep venous thrombosis and even pulmonary embolism may be the initial clinical symptoms and can camouflage the clinical manifestation disease [10].

Leiomyosarcomas arising form smaller vessels are less frequent and may present primarily as nerve compression syndrome [4]. These tumors often protrude through small lumina of adjacent venous branches [7]. One of the patients presented with symptoms of arterial occlusion requiring vascular bypass surgery. Unfortunately in this particular case the delayed diagnosis in conjunction with an incorrect pathological assessment delayed the surgical ablation which permitted tumor progression. At this late time point to the patient refused surgical ablation and instead sought palliative radiation therapy.

Venous branches of the lower extremity as well as the azygos vein have been described as unusual sites of manifestation of intravascular leiomyosarcomata in the current literature [11, 12]. Tumors localised in the upper extremity or the head and neck region are rare exemptions with reports in the literature limited to single cases [3, 1315]. In our intravascular leiomyosarcomas of the extremities there were four patients with a tumor origin of the femoral vein, further two cases of larger subcutaneous vein branches of the thigh, two of the long saphenous vein and most interestingly, three patients where the tumor was found in the upper extremity. Similar to our findings Berlin et al. [7] and Abed et al. [5] described the majority of these vascular leiomyosarcomas as arising from the lower extremity. In the combined studies of Abed et al. [5]and Dzsinich et al. [8] and Berlin et al. only one tumor was found in the upper extremity [7].

It has been indicated that small vein structures are the predominant source of the rare intravascular leiomyosarcomata of the deep somatic soft tissue [16].

The clinical picture may either result form the tumor growth itself or be related to the vascular occlusion manifesting as venous stases or thrombosis. A wide range of differential diagnosis may lead to clinical symptoms of venous stasis in the upper and lower extremity for example lung cancer, lymphomas, post thrombotic syndrome [17]. Intravascular neoplasms result in stasis of the blood flow by intraluminal obstruction [18, 19]. CT scans, MRI, and angiograms [7, 20] demonstrate filling defects in accordance with the clinical signs of vascular compression are valuable diagnostic measures that will facilitate the operative planning when suspecting an intravascular leiomyosarcoma. Particularly MRI can assist in differentiating intravascular tumor growth from thrombosis. In contrast to the intravascular tumor a thrombus commonly presents with a high signal intensity both in the T1 and T2 weighted images whereas the leiomyosarcoma appears as a homogenous tumor with an intermediate signal intensity on T1 - weighted imaging [21]. Moreover CT and MRI will not in all cases allow for an exact image of the endovascular tumor component [19].

An MRI was obtained in all of the presented patients prior to surgical ablation. Two subcutaneous tumors were ablated without imaging of the tumor prior to transfer to our center. The MRI in these patients was conducted before definitive surgery. A preoperative angiogram even though desirable was performed only in the minority of cases. Tumors of the venous vessel wall may present with an intraluminal growth pattern or may extent from the tunica media and infiltrate the surrounding soft tissue [13]. In thin veins especially extension into the perivascular soft tissue may occur early [4].

As vascular leiomyosarcomata are commonly composed of an intraluminal as well as an extravascular tumor component [7] after biopsy diagnosis of a soft tissue leiomyosarcoma the rare possibility of a primary intravascular tumor growth has to be suspected since it may influence the surgical strategy. Primary intravascular tumor growth may necessitate vascular dissection and resection of the tumor bearing course over a longer distance far from the palpable tumor mass due to intraluminal tumor extension [7, 14]. The extravascular component of the sarcomata sometimes requires the resection and reconstruction of the adjacent artery as in 33% of the assessed patients.

In these cases both pre- and postoperative pulmonary microthrombembolism are frequent complications especially for tumors of the pulmonary artery [22]. The lung also is the most common site of distant metastasis [16]. Leiomyosarcomata are malignant tumors of mesenchymal origin with a differention towards smooth muscle morphology. The histological appearance is composed of spindle shaped cells with eosinophilic cytoplasm with muscular striation and cigar shaped rounded nuclei. Immunohistochemical staining for contractile fibers proteins such as actin, desmin as well as h-caldesmon can verify the diagnosis. Standard H&E staining and immunohistochemical staining for smooth muscle markers was performed in all of the cases of this series to confirm the diagnosis.

The differential diagnosis embraces the spectrum of spindle cell shaped neoplasms such as benign and malignant tumors of the nerve sheaths, myofibroblastic tumors (myofibromatosis, fibromatosis, myofibroblastic sarcoma), synovial sarcoma, fibrosarcoma and NOS sarcoma [23].

Intimal sarcoma, malignant mesenchymal tumors of the large arteries which originate from the intimal layer of the vessel wall [24] and the very rare intravascular angiosarcoma belong to the differential diagnosis of malignant intravascular tumors [25].

Surgical ablation with clear margins is the therapy of choice [57].

Vascular leiomyosarcomata are associated with aggressive tumor growth, poorer prognosis and earlier onset of metastatases compared to other soft tissue tumors [26]. The high rate of local recurrence and pulmonary metastases seen in the present study confirm these findings. Adjuvant radiation therapy may aid in local tumor control in the case of incomplete tumor resection or higher tumor grade. Tumor size and localization are of prognostic value [13]. Retroperitoneal leiomyosarcoma has similar out come and prognosis to leiomyosarcoma of the extremities [27].

Intravascular growth is associated with early pulmonary metastasis [16]. The three year survival of 57% in the presented study is consistant with the literature. [57] We recommend to include all patients with leiomyosarcomas in an international database to gain epidemiological data and improve the treatment of these rare tumors.

Conclusion

Leiomyosarcomas rarely arise from blood vessel walls. The clinical presentation is misleading and thrombembolic events may be the first symptoms. Intravascular spread may complicate the surgical resection, rendering it difficult to obtain clear margins. The extravenous tumor component may necessitate resection of the concomitant artery or vein which requires vascular reconstruction. Early hematogenous metastasis and a high rate of local recurrence compromise the prognosis of the disease.

References

  1. Issels R: Manual Knochentumoren und Weichteilsarkome. 2004, München: W Zuckerschwerdt Verlag, 4

    Google Scholar 

  2. Shimoda HOK, Otani S, Hakozaki H, Yoshimura T, Okazaki HNS, Tomita S, Oka T, Kawasaki T, Mori N: Vascular leiomyosarcoma arising from the inferior vena cava diagnosed by intraluminal biopsy. Virchows Arch. 1998, 433: 97-100. 10.1007/s004280050223.

    Article  CAS  PubMed  Google Scholar 

  3. Varela-Duran J, Oliva H, Rosai J: Vascular leiomyosarcoma: the malignant counterpart of vascular leiomyoma. Cancer. 1979, 44: 1684-1691. 10.1002/1097-0142(197911)44:5<1684::AID-CNCR2820440523>3.0.CO;2-I.

    Article  CAS  PubMed  Google Scholar 

  4. Weiss SWGJ: Leiomysarcoma. (Hrsg) Enzinger and Weiss's soft tissue tumors. Edited by: Weiss SW, Goldblum JR. 2001, Mosby, StLouis Baltimore Berlin, 727-748. 4

    Google Scholar 

  5. Abed R, Abudu A, Grimer RJ, Tillman RM, Carter SR, Jeys L: Leiomyosarcomas of vascular origin in the extremity. Sarcoma. 2009, 2009: 385164-10.1155/2009/385164.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Svarvar C, Bohling T, Berlin O, Gustafson P, Folleras G, Bjerkehagen B, Domanski HA, Sundby Hall K, Tukiainen E, Blomqvist C: Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group. Cancer. 2007, 109: 282-291. 10.1002/cncr.22395.

    Article  PubMed  Google Scholar 

  7. Berlin O, Stener B, Kindblom LG, Angervall L: Leiomyosarcomas of venous origin in the extremities. A correlated clinical, roentgenologic, and morphologic study with diagnostic and surgical implications. Cancer. 1984, 54: 2147-2159. 10.1002/1097-0142(19841115)54:10<2147::AID-CNCR2820541015>3.0.CO;2-9.

    Article  CAS  PubMed  Google Scholar 

  8. Dzsinich C, Gloviczki P, van Heerden JA, Nagorney DM, Pairolero PC, Johnson CM, Hallett JW, Bower TC, Cherry KJ: Primary venous leiomyosarcoma: a rare but lethal disease. J Vasc Surg. 1992, 15: 595-603. 10.1067/mva.1992.34346.

    Article  CAS  PubMed  Google Scholar 

  9. Perl L: Ein Fall vom Sarkom der Vena cava inferior. Virchows Arch. 1871, 53: 378-385. 10.1007/BF01957198.

    Article  Google Scholar 

  10. Subramaniam MM, Martinez-Rodriguez M, Navarro S, Rosaleny JG, Bosch AL: Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report. Virchows Arch. 2007, 450: 235-237. 10.1007/s00428-006-0322-2.

    Article  PubMed  Google Scholar 

  11. Dasika U, Shariati N, Brown JM: Resection of a leiomyosarcoma of the azygos vein. Ann Thorac Surg. 1998, 66: 1405-10.1016/S0003-4975(98)00718-8.

    Article  CAS  PubMed  Google Scholar 

  12. Kevorkian J, Cento DP: Leiomyosarcoma of large arteries and veins. Surgery. 1973, 73: 390-400.

    CAS  PubMed  Google Scholar 

  13. Leu HJ, Makek M: Intramural venous leiomyosarcomas. Cancer. 1986, 57: 1395-1400. 10.1002/1097-0142(19860401)57:7<1395::AID-CNCR2820570726>3.0.CO;2-O.

    Article  CAS  PubMed  Google Scholar 

  14. Tovar-Martin E, Tovar-Pardo AE, Marini M, Pimentel Y, Rois JM: Intraluminal leiomyosarcoma of the superior vena cava: a cause of superior vena cava syndrome. J Cardiovasc Surg (Torino). 1997, 38: 33-35.

    CAS  Google Scholar 

  15. Tilkorn DJ, Lehnhardt M, Hauser J, Daigeler A, Hebebrand D, Mentzel T, Steinau HU, Kuhnen C: Intravascular leiomyosarcoma of the brachiocephalic region -- report of an unusual tumour localisation: case report and review of the literature. World J Surg Oncol. 2008, 6: 113-10.1186/1477-7819-6-113.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Farshid G, Pradhan M, Goldblum J, Weiss SW: Leiomyosarcoma of somatic soft tissues: a tumor of vascular origin with multivariate analysis of outcome in 42 cases. Am J Surg Pathol. 2002, 26: 14-24. 10.1097/00000478-200201000-00002.

    Article  PubMed  Google Scholar 

  17. Puleo JG, Clarke-Pearson DL, Smith EB, Barnard DE, Creasman WT: Superior vena cava syndrome associated with gynecologic malignancy. Gynecol Oncol. 1986, 23: 59-64. 10.1016/0090-8258(86)90116-2.

    Article  CAS  PubMed  Google Scholar 

  18. Weiss KS, Zidar BL, Wang S, Magovern GJ, Raju RN, Lupetin AR, Shackney SE, Simon SR, Singh M, Pugh RP: Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome. Cancer. 1987, 60: 1238-1242. 10.1002/1097-0142(19870915)60:6<1238::AID-CNCR2820600613>3.0.CO;2-V.

    Article  CAS  PubMed  Google Scholar 

  19. Izzillo R, Qanadli SD, Staroz F, Dubourg O, Laborde F, Raguin G, Lacombe P: Leiomyosarcoma of the superior vena cava: diagnosis by endovascular biopsy. J Radiol. 2000, 81: 632-635.

    CAS  PubMed  Google Scholar 

  20. Deweese JA, Terry R, Schwartz SI: Leiomyoma of the greater saphenous vein with preoperative localization by phlebography. Ann Surg. 1958, 148: 859-861. 10.1097/00000658-195811000-00027.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Blum U, Wildanger G, Windfuhr M, Laubenberger J, Freudenberg N, Munzar T: Preoperative CT and MR imaging of inferior vena cava leiomyosarcoma. Eur J Radiol. 1995, 20: 23-27. 10.1016/0720-048X(95)00608-S.

    Article  CAS  PubMed  Google Scholar 

  22. Theile A: "Walking pneumonia" in primary sarcoma of the pulmonary artery. Pathologe. 1996, 17: 231-234. 10.1007/s002920050162.

    Article  CAS  PubMed  Google Scholar 

  23. Mentzel TK: Myofibroblastaere Tumoren. Kurzgefasste Uebersicht zur Klinik. Diagnose und Differentialdiagnose. Pathologe. 1998, 19: 176-186. 10.1007/s002920050271.

    Article  CAS  PubMed  Google Scholar 

  24. Bode-Lesniewska BKP: Intimal sarcoma. Fletcher CDM Unni KK Mertens (Hrsg) World Health Organization classification of tumours Pathology and genetics of soft tissue and bone IARC Press. 2002, 223-224.

    Google Scholar 

  25. Hottenrott G, Mentzel T, Peters A, Schroder A, Katenkamp D: Intravascular ("intimal") epithelioid angiosarcoma: clinicopathological and immunohistochemical analysis of three cases. Virchows Arch. 1999, 435: 473-478. 10.1007/s004280050430.

    Article  CAS  PubMed  Google Scholar 

  26. Gow CH, Liaw YS, Chang YL, Chang YC, Yang RS: Primary vascular leiomyosarcoma of the femoral vein leading to metastases of scalp and lungs. Clin Oncol (R Coll Radiol). 2005, 17: 201-

    Article  CAS  Google Scholar 

  27. Hines OJ, Nelson S, Quinones-Baldrich WJ, Eilber FR: Leiomyosarcoma of the inferior vena cava: prognosis and comparison with leiomyosarcoma of other anatomic sites. Cancer. 1999, 85: 1077-1083. 10.1002/(SICI)1097-0142(19990301)85:5<1077::AID-CNCR10>3.0.CO;2-0.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank Dr. Sammy Al - Benna for his critical reading of manuscript and helpful comments and his revision of the language.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel J Tilkorn.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

DT conceptualized the study, gathered the data and wrote the manuscript. JH drafted and revised the manuscript. AR gathered the clinical data and assisted with interpretation of the data. OG reviewed the literature and assisted with the interpretation of the data. IS assessed the histological specimens. HS conceptualized and supervised the process of data gathering and revised the final. CK assessed the histological specimens, aided drafting and manuscript revision. All authors read and approved the final manuscript.

Authors’ original submitted files for images

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Tilkorn, D.J., Hauser, J., Ring, A. et al. Leiomyosarcoma of intravascular origin - a rare tumor entity: clinical pathological study of twelve cases. World J Surg Onc 8, 103 (2010). https://doi.org/10.1186/1477-7819-8-103

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/1477-7819-8-103

Keywords