Tactile corpuscle-like structures, also called tactoid bodies, wagner-meissner-like corpuscles, pacinian corpuscles-like structures and pseudomeissnerian corpuscles are exclusively found in peripheral nerve sheath tumors such as schwannoma, neurofibroma 123456 and neuroid intradermal melanocytic nevi 7. In the classification by Krucke (1974), neurofibromas with these structures were considered a distinct histological subtype (type III neurofibromas) 8. The presence of such structures in plexiform neurofibromas has been associated with von Recklinghausen's disease 6. The cells comprising these structures are arranged in a whorled or lamellated arrangement and are considered to be of perineural and schwannian nature 34.

A 30-year-old caucasian male presented with progressive dysphagia for the past few months. The patient had a history of smoking one pack per day and heavy alcohol use for many years. His medical history was significant for hypertension. An endoscopic biopsy revealed an adenocarcinoma at the gastroesophageal junction. Gross examination of the subsequent esophagogastrectomy specimen revealed a 5.5 × 3.0 × 1.2 cm fungating tumor, located at the gastroesophageal junction. The remaining gastric and esophageal mucosa appeared unremarkable. Sections of the tumor, random sections of uninvolved mucosa and other pertinent sections were examined after hematoxylin and eosin (H&E) staining.

Tactile corpuscle-like structures are neurogenic lamellated formations composed predominantly of Schwann cells or perineural cells or both. They are almost exclusively associated with certain types of nerve sheath tumors and intradermal nevi 910.

In the current report, we describe the presence of such structures in the lamina propria of grossly normal gastric mucosa in a patient with gastroesophageal adenocarcinoma. The morphologic features of these corpuscles are compatible with those described in associated with nerve sheath tumors and the single case of colonic carcinoma. Positive immunohistochemical stains for the nerve cell marker (S-100 and NSE) demonstrate their neurogenic origin. Along with morphologic observations, this immunohistochemical staining pattern supports that these corpuscle-like structures found incidentally in our case, are similar to the tactile corpuscle-like structures described in peripheral nerve sheath tumors or dermal nevi and are of Schwann-related cell origin 4. In fact, several other authors have come to the conclusion that these structures are composed predominantly of Schwann cells 3.

Based on the clinical information, the patient in our case has no history of nerve sheath tumor or tactile corpuscle-like structure related disorder. We do not believe that there is any relationship between these structures and adenocarcinoma in term of tissue origin and since carcinoma is the most common reason for colectomy or esophagogastrectomy, these findings may be purely incidental. On the other hand, it is possible that these corpuscles might be acquired during the neoplastic changes, for which we cannot provide any evidence at present and further analysis of such cases is essential. Could these represent embryonic remnants of sensory nerve system in viscera or have the potential to be a source for the development of neurogenic tumors in lamina propria of gastric mucosa need to be answered. It is worth being mentioned here that gastric submucosal tumors of neurogenic origin with Schwann cell element are not as infrequent as we thought. Yagihashi et al., demonstrated with immunohistochemical techniques that some gastric submucosal tumors, originally diagnosed as leiomyomas and leiomyosarcoma, were actually the tumors of neurogenic origin 11. The most important diagnostic relevance of these findings is to make histopathologists aware that such an entity exists and should not be misinterpreted as a ganglioneuromatous lesion or other neurogenic lesions in small biopsies.

The author(s) declare that they have no competing interests.

BL provided the case for this case report, SA reviewed literature and had the central responsibility in preparing and coordinating writing of the manuscript. MM, HA reviewed literature and helped in preparation of the manuscript. JSH offered valuable experience in writing of this report. All authors read and approved the final manuscript.