An immunohistochemical and ultrastructural study of case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum.
Sarker AB, Hoshida Y, Akagi S, Hayashi K, Murakami I, Jeon HJ, Takahashi K, Akagi T.
Second Department of Pathology, Okayama University Medical School, Japan.
One case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum is reported. The histological appearance of the tumor was identical to pulmonary small-cell carcinoma. Neuroendocrine differentiation was demonstrated immunohistochemically by positive immunoreaction for neuron specific enolase, Leu-7 and chromogranin, and ultrastructurally by the presence of scanty dense-core neurosecretory type granules. Small-cell neuroendocrine carcinoma in the ampulla of Vater is extremely rare. To our knowledge, this is the sixth reported case.
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PMID: 1384272 [PubMed - indexed for MEDLINE]