Your browser version may not work well with NCBI's Web applications. More information here...
1: Jpn J Clin Oncol. 2007 Oct;37(10):793-6. Epub 2007 Aug 24.
Related Articles, Links
Click here to read
Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor.

Yamano T, Morii E, Ikeda J, Aozasa K.

Department of Surgery, Kawachi General Hospital, 1-31 Yokomakura, Higasi-Osaka, 578-0954, Japan. yamanot@kawati.org

Granulocyte colony-stimulating factor (G-CSF)-producing malignancies are thought to be rare and associated with advanced disease and poor prognosis. Here, we report on a 77-year-old patient with G-CSF-producing gastric cancer. We observed this patient from the stage prior to the diagnosis of gastric cancer when leukocyte count was normal to the stage of advanced disease associated with remarkable leukocytosis. Immunohistochemical analysis demonstrated G-CSF expression in the advanced-stage, poorly differentiated adenocarcinoma, but not in the early-stage, well-differentiated adenocarcinoma. G-CSF receptor was not detected to be expressed in the advanced-stage tumor. Based on these results it appears that a histological change in the tumor may influence G-CSF production and the concomitant rapid progression in gastric cancer.

Publication Types:
PMID: 17720735 [PubMed - indexed for MEDLINE]