http://www.wjso.com The latest research articles published by World Journal of Surgical Oncology 2010-08-26T00:00:00Z This is an RSS newsfeed from BioMed Central It is intended to be used with an RSS reader. For more information about RSS newsfeeds from BioMed Central, visit http://www.biomedcentral.com/info/about/rss/ Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered a patient with adenoid cystic carcinoma. A 75-year-old woman showed a nodular lesion with 10mm in diameter in the right upper lung field on chest radiography. The diagnosis was unclear, but lung cancer could not be ruled out. Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung. We enforced upper lobectomy and mediastinal lymph node dissection to the patient. Histopathological examination revealed adenoid cystic carcinoma with a characteristic cribriform structure. Immunohistochemical examination revealed that the tumor cells were positive for thyroid transcription factor 1 (TTF-1), this tumor was diagnosed primary ACC of the lung. http://www.wjso.com/content/8/1/74 Masahiro Kitada Keisuke Ozawa Kazuhiro Sato Satoshi Hayashi Yoshihiko Tokusashi Naoyuki Miyokawa Tadahiro Sasajima World Journal of Surgical Oncology 2010, 8:74 2010-08-26T00:00:00Z doi:10.1186/1477-7819-8-74 World Journal of Surgical Oncology 1477-7819 8 74 2010-08-26T00:00:00Z PDF Background: Albinism is a genetic disorder characterized by lack of skin pigmentation. It has a worldwide distribution, but is commoner in areas close to the equator like Nigeria. Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. Challenges faced in the care of these patients need to be highlighted, in order to develop a holistic management approach, with significant public health impact. The aim of the study was to determine the pattern of skin cancers seen in Albinos, and to highlight problems encountered in their management.MethodCase records of albinos managed in Imo state University teaching Hospital from June 2007 to May 2009 were reviewed. The data obtained were analyzed using descriptive statistics.Results and discussionIn the period under review, albinos accounted for 67% of patients managed for primary skin cancers. There were twenty patients, with thirty eight (38) lesions. Sixty one percent of the patients were below 40 years. Average duration of symptoms at presentation was 26 months. The commonest reason for late presentation was lack of funds. Squamous cell carcinoma was the commonest histologic variant. Most patients were unable to complete treatment due to lack of funds. Conclusion: Albinism appears to be the most important risk factor in the development of skin cancers in our environment. Late presentation and poor rate of completion of treatment due to poverty are major challenges. http://www.wjso.com/content/8/1/73 Kingsley Opara Bernard Jiburum World Journal of Surgical Oncology 2010, 8:73 2010-08-25T00:00:00Z doi:10.1186/1477-7819-8-73 World Journal of Surgical Oncology 1477-7819 8 73 2010-08-25T00:00:00Z PDF Background: Hyperthermic chemotherapy applies thermal energy to both abdominal wall as well as the intra-abdominal viscera. The combination of the hyperthemia, chemotherapy and cytoreductive surgery (CRS) is associated with a defined risk of abdominal wall and intestinal morbidity reported to be as high as 15%, respectively to date, no studies have evaluated the use of biomaterial mesh as adjuvant to abdominal wall closure in this group of patients. In the present report, we hypothesized that post HIPEC closure with a biomaterial can reduce abdominal wall morbidity after CRS and hyperthermic intraperitoneal chemotherapy.Materials and methodsAll patients treated with HIPEC in a tertiary care center over 12 months (2008-2009) period were included. Eight patients received cytoreductive surgery followed by HIPEC for 90 minutes using Mitomycin C (15 mg q 45 minutes × 2). Abdominal wall closure was performed using Surgisis (Cook Biotech.) mesh in an underlay position with 3 cm fascial overlap-closure. Operative time, hospital length of stay (LOS) as well as postoperative outcome with special attention to abdominal wall and bowel morbidity were assessed. Results: Eight patients, mean age 59.7 ys (36-80) were treated according to the above protocol. The primary pathology was appendiceal mucinous adenocarcinoma (n = 3) colorectal cancer (n = 3), and ovarian cancer (n = 2). Four patients (50%) presented initially with abdominal wall morbidity including incisional ventral hernia (n = 3) and excessive abdominal wall metastatic implants (n = 1). The mean peritoneal cancer index (PCI) was 8.75. Twenty eight CRS were performed (3.5 CRS/patient). The mean operating time was 6 hours. Seven patients had no abdominal wall or bowel morbidity, the mean LOS for these patients was 8 days. During the follow up period (mean 6.3 months), one patient required exploratory laparotomy 2 weeks after surgery and subsequently developed an incisional hernia and enterocutaneous fistula. Conclusion: The use of biomaterial mesh in concert with HIPEC enables the repair of concomitant abdominal wall hernia and facilitates abdominal wall closure following the liberal resection of abdominal wall tumors. Biomaterial mesh prevents evisceration on repeat laparotomy and resists infection in immunocompromised patients even when associated with bowel resection. http://www.wjso.com/content/8/1/72 Cherif Boutros Ponandai Somasundar N Joseph Espat World Journal of Surgical Oncology 2010, 8:72 2010-08-20T00:00:00Z doi:10.1186/1477-7819-8-72 World Journal of Surgical Oncology 1477-7819 8 72 2010-08-20T00:00:00Z XML Background: Esophagojejunal fistula is a serious complication after total gastrectomy in gastric cancer patients. This study describes the successful conservative management in 3 gastric cancer patients with esophagojejunal fistula after total gastrectomy using total enteral nutrition. Methods: Between January 2004 to December 2008, 588 consecutive patients with a proven diagnosis of gastric cancer were taken to the operation room to try a curative treatment. Of these, 173 underwent total gastrectomy, 9 of them had esophagojejunal fistula (5.2%). In three selected patients a trans-anastomotic naso-enteral feeding tube was placed under fluoroscopic vision when the fistula was clinically detected and a complete polymeric enteral formula was used. Results: The complete closing of the esophagojejunal fistula was obtained in day 8, 14 and 25 respectively. Conclusion: In some selected cases it is possible to make a successful enteral nutrition using a feeding tube distal to the leak area inserted with the help of fluoroscopic vision. The specialized management of a gastric surgery unit and nutritional therapy unit are highlighted. http://www.wjso.com/content/8/1/71 Michel Portanova World Journal of Surgical Oncology 2010, 8:71 2010-08-16T00:00:00Z doi:10.1186/1477-7819-8-71 World Journal of Surgical Oncology 1477-7819 8 71 2010-08-16T00:00:00Z XML ObjectiveTo study the retropharyngeal lymph node status (RPLN) by pretreatment PET-CT imaging in patients with squamous cell carcinomas of the oropharynx (OPSCC). Study Design: Retrospective. Methods: 101 patients with a biopsy proven OPSCC were identified. 53 patients meeting inclusion criteria were further analyzed. Results: The frequency of RPLN was 20.8% (11/53). Advanced T stage cancer (OR = 5.6250, 95% CI: 1.06 - 29.80, p = 0.0410) and advanced clinical N stage cancer (i.e. N2+) had higher odds (OR = 3.9773, 95% CI: 0.9628 - 16.4291) of being RPLN positive as compared to N0-1 patients. Conclusions: Pre-treatment PET-CT can be used as a staging tool to aid in treatment planning of OPSCC, as rates of RPLN and nodal metastasis are consistent with those reported in the literature. Advanced T and N stage are associated with a greater odds ratio of being RPLN positive by PET-CT imaging. http://www.wjso.com/content/8/1/70 Marcie Tauzin Amy Rabalais Joseph Hagan Charles Wood Robert Ferris Rohan Walvekar World Journal of Surgical Oncology 2010, 8:70 2010-08-16T00:00:00Z doi:10.1186/1477-7819-8-70 World Journal of Surgical Oncology 1477-7819 8 70 2010-08-16T00:00:00Z XML Herein is reported the case of a mantle cell lymphoma (MCL) with synchronous double intestinal location. A 74 - year old male presented with mild abdominal pain. CT scan imaging indicated invasion of lateral intestinal cavity by large mass formation. Exploratory laparotomy was performed and two solid extra-mural masses were isolated and excised. Histology revealed non- polypoid double synchronous lymphoma of mantle cell origin, an unusual presentation of the disease. http://www.wjso.com/content/8/1/69 Nikolaos Sikalias Konstantinos Alexiou Maria Demonakou Sylvia Christina Mylona Theodora Papadaki Nikolaos Ekonomou World Journal of Surgical Oncology 2010, 8:69 2010-08-13T00:00:00Z doi:10.1186/1477-7819-8-69 World Journal of Surgical Oncology 1477-7819 8 69 2010-08-13T00:00:00Z XML The association between schistosomiasis and colorectal malignancy has long been suggested in the literature, but it is not uniformly accepted. In the Far East, considerable evidence supports an etiological link between Schistosoma japonicum and colorectal cancer. However, the available data regarding the role of Schistosoma mansoni in colorectal carcinogenesis are conflicting and most often do not show causality. We report on a patient with sigmoid colonic cancer coexisting with schistosomiasis, and we provide a comprehensive review of the literature regarding the epidemiology and pathobiology of this association. http://www.wjso.com/content/8/1/68 Omer Salim Hytham Suliman Salwa Mekki Suleiman Suleiman Shakir Ibrahim World Journal of Surgical Oncology 2010, 8:68 2010-08-13T00:00:00Z doi:10.1186/1477-7819-8-68 World Journal of Surgical Oncology 1477-7819 8 68 2010-08-13T00:00:00Z XML Background: Adult granulosa cell tumor associated with antecedent use of tamoxifen as adjuvant hormonotherapy for breast cancer is rare. The pathogenesis of this occurrence remains difficult to explain. The estrogenic effect of tamoxifen can be one such explanation.Case presentationA 47 year-old women was treated with surgery, chemotherapy, radiotherapy and tamoxifen for stage III estrogen receptor positive breast carcinoma. Ten months after stopping tamoxifen, we diagnosed a stage Ic granulosa cell tumor of the ovary. Conclusions: Use of tamoxifen has been found to be associated with gynecological tumors like endometrial carcinoma. Its association with granulosa cell tumor of the ovary is uncommon. Only two previous cases have been reported in literature. http://www.wjso.com/content/8/1/67 Halima Abahssain Mouna Kairaouani Wafa Allam Robert Gherman Hind M'Rabti Hassan Errihani World Journal of Surgical Oncology 2010, 8:67 2010-08-12T00:00:00Z doi:10.1186/1477-7819-8-67 World Journal of Surgical Oncology 1477-7819 8 67 2010-08-12T00:00:00Z XML Background: Retroperitoneal Schwannomas are uncommonly found in the retroperitoneum and few of them show malignant transformation and invasion. Local recurrence are common in malignant Schwannomas with very few reports of tumor distinct differentiation at recurrences.Case presentationWe report here a rare case of retroperitoneal schwannoma with multiple origins from retroperitoneum and pelvic wall. Pathological examination confirmed the case as a schwannoma with malignant transformation. Radical dissection of the tumors along with the sacrifice of adjacent sigmoid colon and left kidney failed to provide a cure for this patient. Due to tumor recurrence, a second and a third surgery of radical excision were performed 6 months and 17 months later after the first surgery, respectively. Histopathologic analysis identified that the recurrent tumors were different from the original schwannoma because of their smooth muscle-like differentiation. Conclusion: Malignant schwannomas are uncommon sarcomas with a high incidence of local recurrence. Distinct immunohistochemical staining results of the tumors at recurrence indicate their potential of smooth-muscle like differentiation. Radical excision of the tumors may provide benefit for their local recurrences. http://www.wjso.com/content/8/1/66 Zhong-qi Li Hai-yong Wang Jun Li Li-song Teng World Journal of Surgical Oncology 2010, 8:66 2010-08-09T00:00:00Z doi:10.1186/1477-7819-8-66 World Journal of Surgical Oncology 1477-7819 8 66 2010-08-09T00:00:00Z XML Background: 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is widely used in diagnostic cancer imaging. However, the use of 18F-FDG in PET-based imaging is limited by its specificity and sensitivity. In contrast, anti-TAG (tumor associated glycoprotein)-72 monoclonal antibodies are highly specific for binding to a variety of adenocarcinomas, including colorectal cancer. The aim of this preliminary study was to evaluate a complimentary determining region (CDR)-grafted humanized CH2-domain-deleted anti-TAG-72 monoclonal antibody (HuCC49deltaCH2), radiolabeled with iodine-124 (124I), as an antigen-directed and cancer-specific targeting agent for PET-based imaging. Methods: HuCC49deltaCH2 was radiolabeled with 124I. Subcutaneous tumor implants of LS174T colon adenocarcinoma cells, which express TAG-72 antigen, were grown on athymic Nu/Nu nude mice as the xenograft model. Intravascular (i.v.) and intraperitoneal (i.p.) administration of 124I-HuCC49deltaCH2 was then evaluated in this xenograft mouse model at various time points from approximately 1 hour to 24 hours after injection using microPET imaging. This was compared to i.v. injection of 18F-FDG in the same xenograft mouse model using microPET imaging at 50 minutes after injection. Results: At approximately 1 hour after i.v. injection, 124I-HuCC49deltaCH2 was distributed within the systemic circulation, while at approximately 1 hour after i.p. injection, 124I-HuCC49deltaCH2 was distributed within the peritoneal cavity. At time points from 18 hours to 24 hours after i.v. and i.p. injection, 124I-HuCC49deltaCH2 demonstrated a significantly increased level of specific localization to LS174T tumor implants (p = 0.001) when compared to the 1 hour images. In contrast, approximately 50 minutes after i.v. injection, 18F-FDG failed to demonstrate any increased level of specific localization to a LS174T tumor implant, but showed the propensity toward more nonspecific uptake within the heart, Harderian glands of the bony orbits of the eyes, brown fat of the posterior neck, kidneys, and bladder. Conclusions: On microPET imaging, 124I-HuCC49deltaCH2 demonstrates an increased level of specific localization to tumor implants of LS174T colon adenocarcinoma cells in the xenograft mouse model on delayed imaging, while 18F-FDG failed to demonstrate this. The antigen-directed and cancer-specific 124I-radiolabled anti-TAG-72 monoclonal antibody conjugate, 124I-HuCC49deltaCH2, holds future potential for use in human clinical trials for preoperative, intraoperative, and postoperative PET-based imaging strategies, including fused-modality PET-based imaging platforms. http://www.wjso.com/content/8/1/65 Peng Zou Stephen Povoski Nathan Hall Michelle Carlton George Hinkle Ronald Xu Cathy Mojzisik Morgan Johnson Michael Knopp Edward Martin Duxin Sun World Journal of Surgical Oncology 2010, 8:65 2010-08-06T00:00:00Z doi:10.1186/1477-7819-8-65 World Journal of Surgical Oncology 1477-7819 8 65 2010-08-06T00:00:00Z XML