Table 1

The potential mechanisms of diabetes in PanCa
Parameters Role in PanCa Refs
Pancreatic duct Enlargement Mechanical obstruction [24]
Replication increased Predisposing factor [25]
Hyperinsulinism and insulin resistance Post-insulin receptor defect Impaired glycogen synthesis and storage [27]
Plasma glucagon levels and IAPP Early development of PanCa [28]
Polymorphism of -23HphI (A/T) Pathogenesis of PanCa [29]
Tumor size Increased Decreased postresection survival [31]
Enhanced growth [32]
Genetic variants HK2 R844K GA/AA genotype Increased risk [33]
K-ras codon 12 mutations Increased risk [34]

IAPP, islet amyloid polypeptide; PanCa, pancreatic cancer.

Li et al.

Li et al. World Journal of Surgical Oncology 2012 10:171   doi:10.1186/1477-7819-10-171

Open Data