Table 3

The potential mechanisms of hyperglycemia in PanCa progression
Parameters Expression levels Role in PanCa Refs
RAGE Increased Increased metastatic ability [44,45]
ROS Hydrogen peroxide Increased Enhanced the invasive and [46,48]
Increased migratory activity
Antioxidant MnSOD Decreased Enhanced the invasive and migratory activity [50,51]
enzymes Catalase, glutathione peroxidase Decreased
Decreased
Cytokines and their receptors GDNF and RET Increased Enhanced cell proliferation [55]
EGF Increased Enhanced cell proliferation [56]
EGFR Transactivation Enhanced cell proliferation
NGF Increased Aggravated the process of perineural invasion [58]
P75 Decreased

EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; GDNF, glial cell line-derived neurotrophic factor; MnSOD, manganese superoxide dismutase; NGF, nerve growth factor; PanCa, pancreatic cancer; RAGE, receptor for advanced glycation end products; ROS, reactive oxygen species; uPA, urokinase plasminogen activator.

Li et al.

Li et al. World Journal of Surgical Oncology 2012 10:171   doi:10.1186/1477-7819-10-171

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