Table 3 |
||||
| The potential mechanisms of hyperglycemia in PanCa progression | ||||
| Parameters | Expression levels | Role in PanCa | Refs | |
| RAGE | Increased | Increased metastatic ability | [44,45] | |
| ROS | Hydrogen peroxide | Increased | Enhanced the invasive and | [46,48] |
| Increased | migratory activity | |||
| Antioxidant | MnSOD | Decreased | Enhanced the invasive and migratory activity | [50,51] |
| enzymes | Catalase, glutathione peroxidase | Decreased | ||
| Decreased | ||||
| Cytokines and their receptors | GDNF and RET | Increased | Enhanced cell proliferation | [55] |
| EGF | Increased | Enhanced cell proliferation | [56] | |
| EGFR | Transactivation | Enhanced cell proliferation | ||
| NGF | Increased | Aggravated the process of perineural invasion | [58] | |
| P75 | Decreased | |||
EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; GDNF, glial cell line-derived neurotrophic factor; MnSOD, manganese superoxide dismutase; NGF, nerve growth factor; PanCa, pancreatic cancer; RAGE, receptor for advanced glycation end products; ROS, reactive oxygen species; uPA, urokinase plasminogen activator.
Li et al. World Journal of Surgical Oncology 2012 10:171 doi:10.1186/1477-7819-10-171
