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Open Access Case report

A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review

Wei Zhang1, Zhichun Lin2, Tongxian Zhang1, Fen Liu1 and Yun Niu1*

Author Affiliations

1 Breast Pathology Department and Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key laboratory of Cancer Prevention and Therapy of Tianjin, West Huanhu Road, Ti Yuan Bei, Hexi District, Tianjin 300060, China

2 Center for PET-CT, Pingjin Hospital, Logistics University of Chinese People’s Armed Police Forces, Chenglin Road, Tianjin, Hedong District, 300162, China

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World Journal of Surgical Oncology 2012, 10:251  doi:10.1186/1477-7819-10-251

Published: 20 November 2012


We report a case of pure invasive cribriform carcinoma of the breast, which had been untreated for thirteen years, being found with bone metastasis at initial presentation, because distant metastasis is rarely found in this tumor. A fifty-nine-year-old postmenopausal woman presented with a large left breast mass. Although she had noticed a lump in a left breast thirteen years ago, she had not sought treatment. The tumor had enlarged gradually since from one year before and become ulcerated. The two enlarged axillary lymph nodes were also palpable. After two cycles of neoadjuvant chemotherapy, she underwent left radial mastectomy with a free skin graft. Emission computed tomography result has confirmed bone metastasis. The histological diagnosis of the tumor revealed the pure invasive cribriform carcinoma, since over than ninety percent of invasive tumor components showed a characteristic cribriform growth, and the remainder was tubular carcinoma. She has been well without evidence of tumor recurrence for seven years after surgery and several routine postoperative therapies. Although with favorable prognosis, pure invasive cribriform carcinoma is still possible to develop into the advanced (Stage four) breast cancer if untreated for a long time. However, the survival of this patient for free disease after several locoregional and systemic therapies maybe provide a supplement for invasive cribriform carcinoma’s excellent prognosis.

Pure invasive cribriform carcinoma; Breast; Bone metastasis