Research

Fibrin sealant does not decrease seroma output or time to drain removal following inguino-femoral lymph node dissection in melanoma patients: A randomized controlled trial (NCT00506311)

Melinda M Mortenson¹ , Yan Xing¹ , Storm Weaver¹ , Jeffrey E Lee¹ , Jeffrey E Gershenwald¹ , Anthony Lucci¹ , Paul F Mansfield¹ , Merrick I Ross¹ and Janice N Cormier^1,2

¹Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

²Associate Professor of Surgery and Biostatistics, Department of Surgical Oncology-Unit 444, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-1402, USA

author email corresponding author email

World Journal of Surgical Oncology 2008, 6:63doi:10.1186/1477-7819-6-63

Published:	18 June 2008

Abstract

Background

This study assessed the impact of closed suction drains and evaluated whether the intraoperative use of a fibrin sealant decreased time to drain removal and wound complications in melanoma patients undergoing inguino-femoral lymph node dissection.

Methods

A pilot study (n = 18) assessed the impact of a closed suction drain following inguino-femoral lymph node dissection. A single-institution, prospective trial was then performed in which patients were randomized to a group that received intraoperative application of a fibrin sealant following inguino-femoral lymph node dissection or to a control group that did not receive sealant.

Results

The majority of the patients enrolled felt the drains caused moderate or severe discomfort and difficulties with activities of daily living. Thirty patients were then randomized; the median time to drain removal in the control group (n = 14) was 30 days (range, 13–74) compared to 29 days (range, 11–45) in the fibrin sealant group (n = 16; P = 0.6). Major and minor complications were similar in the two groups.

Conclusion

Postoperative closed suction drains were associated with major patient inconvenience. Applying a fibrin sealant at the time of inguino-femoral lymph node dissection in melanoma patients did not reduce the time to drain removal or postoperative morbidity. Alternative strategies are needed.