The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis
- Equal contributors
1 Department of Internal Medicine, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA
2 Department of Pathology, Memorial Medical Center, 701 North First Street, Springfield, IL 62781, USA
3 Department of Surgery, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA
4 Division of Hematology-Oncology, Department of Internal Medicine, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA
5 Simmons Cancer Institute at Southern Illinois University, Post Office Box 19677, Springfield, IL 62794-9677, USA
World Journal of Surgical Oncology 2010, 8:51 doi:10.1186/1477-7819-8-51Published: 21 June 2010
To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.
In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.
Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.
Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.