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1: Cytokine Growth Factor Rev. 2006 Aug;17(4):305-23. Epub 2006 Apr 18.
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Regulation of apoptosis by insulin-like growth factor (IGF)-I.

Kooijman R.

Department of Pharmacology, Free University of Brussels (VUB), Laarbeeklaan 103, B-1090 Brussels, Belgium. ron.kooijman@vub.ac.be

IGF-I is important for fetal and post-natal development, but it also controls tissue homeostasis throughout life via regulation of cell proliferation and apoptosis. This review summarizes our current understanding of how IGF-I receptor signaling interferes with the apoptotic machinery of the cell. IGF-I acts at different control points of apoptosis, including the Bcl-2 family proteins, inhibitors of caspases and signaling of death-inducing receptors. The main focal point of IGF-I is the regulation of Bcl-2 family proteins. Several signaling pathways converge to both the phosphorylation and transcriptional regulation of these proteins. This phenomenon may explain the efficacy of IGF-I as an inhibitor of apoptosis in many different cell types and in the presence of different apoptogenic stimuli.

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PMID: 16621671 [PubMed - indexed for MEDLINE]